Author

Maxim Braverman

Northeastern UniversityORCID 0000-0003-4097-7687Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Dori C. WoodsiD· 2 shared Douglass M. TurnbulliD· 2 shared Jonathan L. TillyiD· 2 shared Konstantin KhrapkoiD· 2 shared Konstantin Yu. PopadiniD· 2 shared Mark KhrapkoiD· 2 shared Melissa FrancoiD· 2 shared Sarah J. PickettiD· 2 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenomics

Dori C. WoodsORCID

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2 papers

Recent·Most cited

GenomicsbioRxivPreprintNov 21, 2023

A novel, wave-shaped profile of germline selection of pathogenic mtDNA mutations is discovered by bypassing a classical statistical bias.

Melissa Franco, Auden Cote-L’Heureux, Zoë Fleischmann…·Konstantin Khrapko

This paper reveals a wave-shaped germline selection profile of mtDNA mutations by correcting for regression to the mean bias, showing how mutations are filtered in the germline.

5 citations

DNA methylationstatistical model

𝕏 PostBluesky

GenomicsbioRxivPreprintFeb 26, 2021

Dynamics of the most common pathogenic mtDNA variant m.3243A>G demonstrate frequency-dependency in blood and positive selection in the germline.

Melissa Franco, Sarah J. Pickett, Zoë Fleischmann…·Konstantin Khrapko

This paper shows that the m.3243A>G mtDNA mutation levels in blood change in a bi-phasic way with age, requiring an age correction dependent on mutation level, and finds evidence for positive germline selection of this mutation.

4 citations

humanDNA methylation

𝕏 PostBluesky