Author

Thomas D. Ryan

Cincinnati Children's Hospital Medical CenterORCID 0000-0003-4237-576XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:variant effect prediction· 2 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Assay:GWAS summary statistics· 1 Assay:protein structure· 1

Frequent Co-Authors

Adam S. HelmsiD· 2 shared Alessia Argiro· 2 shared ANJALI TIKU OWENSiD· 2 shared Carolyn Yung HoiD· 2 shared Dominic James AbramsiD· 2 shared Euan Angus AshleyiD· 2 shared Iacopo OlivottoiD· 2 shared J. Rossano· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Adam S. HelmsORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Reclassification of Genetic Variants in Patients with Hypertrophic Cardiomyopathy from the Sarcomeric Human Cardiomyopathy Registry (SHaRe)

Sophie Hespe, G. Powell, Laura Catto, Natalie Stewart, Amy Baker, Neesha Krishnan, Lucas A Mitchell, Natasha Henden, Ebony Richardson, Alexandra Butters, Pantazis Theotokis, Rachel Buchan, Kathryn A. McGurk, Brian Lee Claggett, Dominic James Abrams, , Jodie Ingles

The paper reclassifies genetic variants in HCM patients using a large registry, finding 10% of variants were reclassified, with most VUS unlikely to be causal.

Heart Lung and Circulation · Jul 30, 2026Peer-reviewedGenetic & Genomic Medicine

Spatial genomics of the cardiac sarcomere

Christian Cadisch, Victoria Nicole Parikh, Megan E. Grove, Aditya Singh, Dominic James Abrams, Neal K. Lakdawala, Carolyn Yung Ho, Erin Miller, Thomas D. Ryan, J. Rossano, Kimberly Y. Lin, Anna Axelsson Raja, Henning Bundgaard, Michelle Michels, Peter-Paul M. Zwetsloot, , Euan Angus Ashley

The paper integrates genomic and structural data to identify variant intolerance regions in cardiac sarcomere genes and links them to disease mechanisms in hypertrophic cardiomyopathy.

bioRxiv · Oct 7, 2025 · PreprintGenomics