Ramesh Chandra Deka

The paper examines synonymous SNPs in E. coli to show strand and expression-dependent mutagenesis, finding that certain transitions are more frequent on the leading strand and influenced by gene expression.

This study uses DFT to calculate binding energies of base pairs, showing transition mutations are more stable than transversion mutations, supporting their higher frequency in genomes.

The paper examines polymorphism in intergenic regions and four-fold degenerate sites in bacterial genomes to explain nucleotide compositional strand asymmetry, finding that FFS polymorphisms, not IRs, explain the asymmetry.