Temporal Optimization of Radiation Therapy to Heterogeneous Tumour Populations and Cancer Stem Cells
Cameron Meaney, Mohammad Kohandel, Arian Novruzi
This paper develops a mathematical model and optimization algorithm to determine optimal radiation therapy schedules for heterogeneous tumours, finding that the ratio of radiosensitivities between cell types is key to predicting optimal dose distribution.
Journal of Mathematical Biology · Oct 13, 2022Peer-reviewedSystems Biology