Author

Lea Ann Chen

Rutgers, The State University of New JerseyORCID 0000-0003-4675-9453Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Lea Ann Chen1 paper

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Adam FrankishiD· 1 shared Adolfo CorreaiD· 1 shared Aiden Peter CorviniD· 1 shared Amina A AbubakariD· 1 shared André FrankeiD· 1 shared Benjamin GläseriD· 1 shared Beryl B. CummingsiD· 1 shared Bruce M. CoheniD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperGenomics

Adam FrankishORCID

Mutual co-authors in cluster

Author profile →

1 paper

Recent·Most cited

Exploring penetrance of clinically relevant variants in over 800,000 humans from the Genome Aggregation Database

Sanna Gudmundsson, Moriel Singer‐Berk, Sarah L. Stenton, Julia K. Goodrich, Michael W. Wilson, Jonah E. Einson, Nicholas A. Watts, Maria Teresa Abreu, Amina A Abubakar, Rolf Adolfsson, Carlos Alberto Aguilar-Salinas, Tariq Ahmad, Christine M. Albert, Jessica Alföldi, Matthieu Allez, , Fernando S. Goes

The paper analyzes over 800,000 human genomes to assess penetrance of clinically relevant variants, finding that 95% of pLoF variants in severe diseases have explanations for lack of disease manifestation.

Nature Communications · Oct 31, 2025Peer-reviewedGenomics