Matthieu Allez

Type 6 secretion systems of adherent-invasive Escherichia coli isolated from Crohn's disease patients shape intestinal microbiota.

This study shows that T6SS genes are more prevalent in Crohn's disease patients' microbiota and functionally impact gut microbiota composition in mice.

Exploring penetrance of clinically relevant variants in over 800,000 humans from the Genome Aggregation Database

The paper analyzes over 800,000 human genomes to assess penetrance of clinically relevant variants, finding that 95% of pLoF variants in severe diseases have explanations for lack of disease manifestation.

Susceptibility to inflammatory bowel diseases promotes invasive carcinomas in a murine model of ATF6-driven colon cancer

This study shows that IBD susceptibility increases the risk of ATF6-driven tumorigenesis in a murine model.

Antigen-driven expansion of public clonal T cell populations in inflammatory bowel diseases

The paper identifies public TCRB sequences expanded in CD or UC, associated with HLA alleles and antigen-specific immune responses, showing differential expansion in CD compared to UC and healthy controls.

T cell mediated impairment of epithelial integrity in Crohn's disease

This study shows that T lymphocytes from Crohn's disease patients impair intestinal epithelial integrity through increased cytotoxicity and altered immune responses in a 3D coculture model.

Sequencing of over 100,000 individuals identifies multiple genes and rare variants associated with Crohns disease susceptibility

The paper identifies ten new genes with coding variants linked to Crohn's disease risk using sequencing data from over 30,000 patients and 80,000 controls.