Cerebellar structural and functional alterations during morphine self-administration are associated with motivation and disrupted goal-directed actions in male Wistar rats
Mariana Stefania Serrano-Ramirez, Jalil Rasgado‐Toledo, David Medina-Sánchez, Luis A. Trujillo-Villarreal, César J. Carranza‐Aguilar, Eduardo A. Garza‐Villarreal
This study shows that morphine self-administration in rats leads to cerebellar structural changes and altered functional connectivity, associated with disrupted goal-directed behavior and increased motivation.
bioRxiv · Apr 27, 2026 · PreprintNeuroscience