NeurosciencebioRxivPreprint
Mosaic human cortical organoids model mTOR-related focal cortical dysplasia through DEPDC5 loss-of-function
Marina Maletic, Sara Bizzotto, Théo Ribierre…·Stéphanie Baulac
This study uses mosaic DEPDC5 variants in human cortical organoids to model FCDII, showing increased mTOR activity and neuronal dysmorphology.