Subchondral bone remodeling in knee osteoarthritis is coupled to lipid mobilization from bone marrow adipocytes
Léa Loisay, Sabrina Bouagga, Diego de Haro, Elke Moradpour, Lorraine Ruffieux, Souad Daamouch, Alex Kanmacher, Thibaut Royon, Alexander Antoniadis, Thomas Hügle, Jeroen J.G. Geurts
This study investigates the link between lipid mobilization from bone marrow adipocytes and bone formation in knee osteoarthritis, finding that lipolysis is associated with osteogenic activity and can be pharmacologically modulated.
bioRxiv · Oct 14, 2026 · PreprintPhysiology