Fatma Senguler Ciftci

Spanning-Tree Thermostatistics of Protein Allostery: An Exact Kirchhoff Framework with Application to Oncogenic KRAS

Kirchhoff matrix-tree evaluation of residue-contact spanning-tree ensembles yields exact allosteric thermodynamics; KRAS G12D conserves global and channel heat capacity but reroutes paths via Q61 and F156.

Flexibility Drives Information Flow in Proteins: Fluctuation Potential Gradients Dictate Directional Entropy Transfer

The paper introduces a matrix framework to map directional entropy transfer in proteins by incorporating continuous distance-dependent weighting into the Kirchhoff matrix, applied to KRAS to identify allosteric communication pathways.

The Geometry of Allostery: A Laplacian Minor Hierarchy for Many-Body Protein Communication

This paper introduces a mathematical framework to analyze allostery in proteins, showing how mutations affect pathway correlations and communication through intermediary residues.

Generalizing the Gaussian Network Model: Spanning-TreeThermodynamics Shows Entropy-Driven KRAS Activation

This paper generalizes the Gaussian Network Model using spanning-tree thermodynamics to show that KRAS activation is driven by entropy-enthalpy compensation.