A systems-level model of sleep-dependent memory-consolidation failure in neurodegeneration: the spindle-slow-oscillation decoupling cascade dissociates amyloid and tau
Bahaa Masry, Anas Shahin, Zeina S. Malek
The paper builds a systems-level model of sleep-dependent memory consolidation in neurodegeneration, showing that amyloid and tau impair memory through distinct mechanisms involving SO-spindle coupling and replay order.
bioRxiv · Sep 29, 2026 · PreprintNeuroscience