LOESS and DE-SWAN can induce artifactual "waves" of molecular aging
M. A. Carbonneau, Katherine Hoff Shutta, Jeffrey W. Miller, Michael P. Snyder, Xiaotao Shen, John F Quackenbush
This paper shows that LOESS and DE-SWAN can create false 'waves' of molecular aging in data, challenging their statistical validity.
bioRxiv · Jun 28, 2026 · PreprintBioinformatics