Deciphering Tumor Microenvironment Dynamics in Tumorigenesis and Lymph Node Metastasis of Esophageal Squamous Cell Carcinoma using Single-Cell RNA Sequencing
H. K. Na, Tae Hee Hong, Chung Lee, Young Ho Yang, Ha Eun Kim, Byung Jo Park, Hyun Ki Kim, Dae Joon Kim
This study uses single-cell RNA sequencing to analyze immune and stromal differences between primary tumors and metastatic lymph nodes in ESCC, revealing distinct exhaustion trajectories and suppressive circuits.
bioRxiv · Nov 27, 2025 · PreprintCancer Biology