Exploring evolution to uncover insights into protein mutational stability
Pauline Hermans, Matsvei Tsishyn, Martin Schwersensky, Marianne J. Rooman, Fabrizio Pucci
The paper evaluates how evolutionary models predict protein stability using deep mutational scanning data and finds that simple models perform as well as complex ones when combined with structural features.
Molecular Biology and Evolution · Dec 27, 2024Peer-reviewedBioinformatics