Mechanistic Insights into the Substrate Egress Pathways of Human Glucose Transporters GLUT1 and GLUT9
Manming Xu, Jiwen Jiang, Lin Gao, Saleh Alyemni, Shozeb M Haider
This study uses machine learning and molecular dynamics to analyze substrate egress pathways in GLUT1 and GLUT9, revealing key residues and conformational changes, and showing apigenin inhibits GLUT9 via steric hindrance.
bioRxiv · Mar 4, 2025 · PreprintBiophysics