Evolutionary BiologyGenome Biology and EvolutionPeer-reviewed
Beyond Invariable Sites: Using Evolutionary Stasis to Map Multi-Layered Constraints on the Evolution of Viral and Mammalian Genomes
Sergei L. Kosakovsky Pond, Hannah Verdonk, Steven Weaver…·Darren Patrick Martin
This paper introduces B-STILL, a Bayesian framework to detect functional constraints in genomes by analyzing evolutionary stasis, identifying significant clusters of invariant sites in viral and mammalian genomes.