Towards Optimizing Target Engagement in Non-Invasive Trigeminal Nerve Stimulation: Anatomical Characterization and Computational Modeling of the Human Trigeminal Nerve
Jennifer L Perrault, Keith D. Kozma, Weifeng Zeng, Zeeda H. Nkana, Nicholas J. Albano, Kirsten A. Gunderson, Samuel A. Hurley, Wendell B. Lake, Justin C. Williams, Samuel O. Poore, Kip A. Ludwig, Aaron M. Dingle, Aaron J. Suminski
This paper characterizes the anatomy of trigeminal nerve branches and uses computational models to show that superficial branches activate nociceptors more than nerve trunks, suggesting potential off-target effects.
bioRxiv · Jun 19, 2025 · PreprintNeuroscience