Choi byung hyug

Sequence-based variant-effect predictions reveal trait-specific regulatory-layer profiles of complex-trait heritability

The paper uses sequence-based variant-effect predictions to show that different regulatory layers contribute variably to the heritability of complex traits within tissues.

Expression predictions inform molecular interpretation of Alzheimer's disease risk loci

The paper evaluates how expression predictions from sequence models correlate with genetic associations in Alzheimer's disease risk loci, finding modest but significant relationships that suggest their utility as complementary evidence.