Passenger co-deletion confounds glutaminolysis signatures anchored on PTEN loss: a cautionary case for location-aware signature design
Abdelmuhsen M. Abusneina, Soad M. Elwirfli
The paper shows that a glutaminolysis signature correlates with PTEN copy-number loss not due to metabolic changes but because of passenger co-deletion, highlighting the need for location-aware signature design.
bioRxiv · Sep 22, 2026 · PreprintCancer Biology