When Does a Pathway Score Preserve a Mediated Effect? Aggregation Geometry, Minimax Adequacy, and Gap Inference for High-Dimensional Mediation
The paper analyzes when pathway scores preserve mediated effects in high-dimensional mediation, introducing a minimax adequacy loss and evaluating performance on TCGA lung adenocarcinoma data.
bioRxiv · Oct 8, 2026 · PreprintBioinformatics