Biologically-informed self-supervised learning for segmentation of subcellular spatial transcriptomics data
Xiaohang Fu, Yingxin Lin, David Ming Lin, Daniel Mechtersheimer, Chuhan Wang, Farhan Ameen, Shila Ghazanfar, Ellis Patrick, Jinman Kim, Jean Yee Hwa Yang
BIDCell improves subcellular spatial transcriptomics segmentation by combining self-supervised learning with biologically informed loss functions, outperforming existing methods across multiple tissue types.
bioRxiv · Jun 13, 2023 · PreprintBioinformatics