Pyruvate partitioning defines an immunosuppressive metabolic niche in colorectal cancer
Jiawei Zheng, Bin Lian, Shiyin Huang, Jinyuan Liu, Yingxin Wu, Huiling Zhai, Yanlin Qiu
The paper defines a Pyruvate Partitioning Index (PPI) to analyze pyruvate metabolism across cell types and tissue space in colorectal cancer, finding it correlates with immune programs and survival.
bioRxiv · Oct 19, 2026 · PreprintCancer Biology