Self-Exciting Population Event Models Reveal Abnormal Temporal Amplification in MAPT-Mutant Human Brain Assembloids
Tonmoy Monsoor, Colin M. McCrimmon, Prateik Sinha, Lina Zhang, Manoj Reddy Dareddy, Mehmet E. Lorasdagi, Ranmal Aloka Samarasinghe, Vwani Roychowdhury
The paper introduces a self-exciting population model to analyze calcium-imaging data from human brain assembloids, revealing increased history-dependent amplification in MAPT mutants.
bioRxiv · Oct 8, 2026 · PreprintNeuroscience