Structural Characterization of mRNA Lipid Nanoparticles in the Presence of Intrinsic Drug-free Lipid Nanoparticles
Xiaoxia Chen, Yongfeng Ye, Mengrong Li, Taisen Zuo, Zhenhua Xie, Yubin Ke, He Cheng, Liang Hong, Zhuo Liu
This study identifies and quantifies drug-free lipid nanoparticles in mRNA-LNPs using SANS and nano flow cytometry, leading to more accurate structural models.
Journal of Controlled Release · Jul 31, 2025Peer-reviewedBiophysics