Author

Manuel Lubetzki

Helmholtz MunichORCID 0009-0008-1013-4164Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Approach:benchmark study· 1 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:machine learning (classical)· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1 Research Focus:trajectory inference· 1

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Alejandro Tejada-LapuertaiD· 1 shared Alessandro PalmaiD· 1 shared Dominik KleiniD· 1 shared Egor AntipoviD· 1 shared Fabian Joachim TheisiD· 1 shared Francesco Paolo CasaleiD· 1 shared Louis Benedikt Kuemmerle· 1 shared Malte D. LueckeniD· 1 shared

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BioinformaticsbioRxivPreprintJun 18, 2026

Benchmarking gene expression reconstruction from single-cell latent representations

Xiaotong Fu, Dominik Klein, Egor Antipov…·Fabian Joachim Theis

The paper benchmarks gene expression reconstruction from single-cell latent representations, finding autoencoders perform best at low dimensionality and foundation models depend on decoder architecture.

DOI 10.64898/2026.06.15.731445

scRNA-seqstatistical model

𝕏 PostBluesky