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bioRxivPharmacology & ToxicologyPreprint

Green synthesis, characterization, and potential antimicrobial studies of Ag-MgO nanocomposites mediated from Talinum triangulare leaf extract

Gildas Fonye Nyuyfoni, Awawou G. PaboudamiD, Kwati LeonardiD, Gilbert Njowir Ndzeidze, François Eya’ane MevaiD

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Abstract

In this study, Ag-MgONCs (silver-magnesium oxide nanocomposites) were fabricated using Talinum triangulare leaf extract as a renewable, mild reducing, and stabilizing agent. The synthesis process involved molecular interactions between pre-prepared AgNPs (silver nanoparticles) and in situ-prepared MgO. Confirmation of the nanocomposites came from micrographic images obtained through SEM-EDX analysis. Dynamic light scattering (DLS) revealed a characteristic nanocomposite size of 295 nm. The infrared spectrum (FTIR) proved interactions between T. triangulare and Ag. Additionally, X-ray patterns of AgNPs and Ag-MgONCs confirmed hexagonal and cubic crystalline states, respectively, with average particle sizes of 17 nm. Furthermore, an in vitro analysis against five bacterial strains (Escherichia coli, Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Proteus mirabilis) revealed pronounced activity of the nanocomposites, particularly against Proteus mirabilis, indicating bactericidal potential.

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