bioRxivMicrobiologyPreprint
The fallacy of identification by neutralization in the light of cytopathology nonproducing enterovirus strains
Moses Olubusuyi AdewumiiD, Temitope Oluwasegun Cephas FaleyeiD, Johnson Adekunle AdenijiiD
Abstract
We describe the characterization of an enterovirus isolate recovered from untreated raw sewage in Ibadan, southwest Nigeria in 2010. The isolate was neutralized by specific antisera and consequently identified as Echovirus 7 (E7). Subsequent molecular characterization showed the isolate to be a mixture of E7 and Coxsackievirus A24 (CV-A24) thereby suggesting the CV-A24 strain to be non-cytopathology producing. Further molecular analysis suggested that the CV-A24 might have recombined with a Sabin poliovirus 2 (PV2) in its non-structural region. This is the first description of a Nigerian CV-A24 strain.
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