Intersubject consistent dynamic connectivity during natural vision revealed by functional MRI

Abstract

The functional communications between brain regions are thought to be dynamic. However, it is usually difficult to elucidate whether the observed dynamic connectivity is functionally meaningful or simply due to noise during unconstrained task conditions such as resting-state. During naturalistic conditions, such as watching a movie, it has been shown that local brain activities, e.g. in the visual cortex, are consistent across subjects. Following similar logic, we propose to study intersubject correlations of the time courses of dynamic connectivity during naturalistic conditions to extract functionally meaningful dynamic connectivity patterns. We analyzed a functional MRI (fMRI) dataset when the subjects watched a short animated movie. We calculated dynamic connectivity by using sliding window technique, and quantified the intersubject correlations of the time courses of dynamic connectivity. Although the time courses of dynamic connectivity are thought to be noisier than the original signals, we found similar level of intersubject correlations of dynamic connectivity to those of regional activity. Most importantly, highly consistent dynamic connectivity could occur between regions that did not show high intersubject correlations of regional activity, and between regions with little stable functional connectivity. The analysis highlighted higher order brain regions such as the default mode network that dynamically interacted with posterior visual regions during the movie watching, which may be associated with the understanding of the movie. HighlightsO_LIIntersubject consistency may provide a complementary approach to study brain dynamic connectivity C_LIO_LIWidespread brain regions showed highly consistent dynamic connectivity during movie watching, while these regions themselves did not show highly consistent regional activity C_LIO_LIConsistent dynamic connectivity often occurred between regions from different functional systems C_LI