Journal of Advanced ResearchMolecular BiologyPeer-reviewed journal article
Non-invasive and painless mid-infrared modulation increases collagen in human and mouse skin
Zeyu Wang, Jiahui ZhuiD, Yuting Wang, Tianxing Hu, Shuai CheniD, Senlin Xu, Yaoying Li, Xiang LiaoiD, Shanshan LiangiD, Yang E. Li, Xuanyue Wang, Sunny C. LiiD, Yan Yang, Hongbo JiaiD, Xiaowei CheniD, Xing Fan, Lan Ge, Jianxiong ZhangiD
Abstract
Stimulating collagen production in skin helps to enhance vitality while decelerating aging- associated processes in skin tissue. However, current approaches to enhancing collagen production are commonly limited by accompanying pain and trauma. Here, we report that mid-infrared modulation (MIMO) at an intensity of 70 mW/cm2 promotes collagen production in human or mouse skin in vivo without generating excessive heat. We found that protein levels of the collagen- degrading endopeptidase, MMP-1, were decreased in the skin of mice following MIMO treatment, whereas the collagen synthesis-related factors, TGF-{beta}, HSP47, and HSP70, were all increased. In addition, MIMO stimulated collagen secretion in human dermal fibroblasts in vitro. This work demonstrates that MIMO is an effective, non-invasive, and painless intervention for in vivo enhancement of collagen production in the skin. One Sentence SummaryMid-infrared modulation promotes collagen production
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