Hippocampal-cortical functional connectivity during memory encoding and retrieval

Abstract

Memory encoding and retrieval are critical sub-processes of episodic memory. While the hippocampus is involved in both, its connectivity with the neocortex during memory processing in humans has been elusive. This is partially due to variations in demands in common memory tasks, which inevitably recruit cognitive processes other than episodic memory. Conjunctive analysis of data from different tasks with the same core elements of encoding and retrieval can reduce the intrusion of patterns related to subsidiary perceptual and cognitive processing. Leveraging data from two large-scale functional resonance imaging studies with different episodic memory tasks (514 and 237 participants), we identified core hippocampal-cortical networks active during memory processing. Anterior and posterior hippocampus had distinct connectivity profiles, which were stable across resting state and memory tasks. Whereas no encoding-specific connectome emerged across tasks, during retrieval hippocampal connectivity was increased with areas known to be active during recollection, including medial prefrontal, inferior parietal, and parahippocampal cortices. This indicates that the stable functional connectivity of the hippocampus along its longitudinal axis is superposed by increased functional connectivity with the recollection network during retrieval, while encoding connectivity likely reflects contextual factors.