Information theoretic evidence for predictive coding in the face processing system

Abstract

Predictive coding suggests that the brain infers the causes of its sensations by combining sensory evidence with internal predictions based on available prior knowledge. However, the neurophysiological correlates of (pre-)activated prior knowledge serving these predictions are still unknown. Based on the idea that such pre-activated prior knowledge must be maintained until needed we measured the amount of maintained information in neural signals via the active information storage (AIS) measure. AIS was calculated on whole-brain beamformer-reconstructed source time-courses from magnetoencephalography (MEG) recordings of 52 human subjects during the baseline of a Mooney face/house detection task. Pre-activation of prior knowledge for faces showed as alpha- and beta-band related AIS increases in content specific areas; these AIS increases were behaviourally relevant in brain area FFA. Further, AIS allowed decoding of the cued category on a trial-by-trial basis. Moreover, top-down transfer of predictions estimated by transfer entropy was associated with beta frequencies. Our results support accounts that activated prior knowledge and the corresponding predictions are signalled in low-frequency activity (<30 Hz).\n\nSignificance statementOur perception is not only determined by the information our eyes/retina and other sensory organs receive from the outside world, but strongly depends also on information already present in our brains like prior knowledge about specific situations or objects. A currently popular theory in neuroscience, predictive coding theory, suggests that this prior knowledge is used by the brain to form internal predictions about upcoming sensory information. However, neurophysiological evidence for this hypothesis is rare - mostly because this kind of evidence requires making strong a-priori assumptions about the specific predictions the brain makes and the brain areas involved. Using a novel, assumption-free approach we find that face-related prior knowledge and the derived predictions are represented and transferred in low-frequency brain activity.