electronic health records

A complete adult Drosophila melanogaster brain tracheolar network

The paper manually traces and analyzes the tracheolar network in the adult Drosophila brain using electron microscopy data, revealing its structure and spatial relationship with neurons.

A medial entorhinal connectome reveals compartmentalized microcircuit architecture

This paper maps the synaptic architecture of the medial entorhinal cortex at synapse resolution, revealing compartmentalized microcircuit organization and potential mechanisms for spatial navigation.

Autophagy activator AA-20 engages CDK5 to promote lipophagy and improve neurodegeneration-associated phenotypes

AA-20 promotes lipophagy by activating lysosomal acid lipase and CDK5, reducing lipid droplet accumulation and improving neurodegeneration-associated phenotypes in cellular and organoid models.

Dynamic adhesion device of phage OE33PA drives Gram-positive host recognition

This study reports cryo-EM structures of phage OE33PA, revealing a dynamic adhesion device that mediates Gram-positive host recognition through receptor-binding proteins and a hexameric tape measure protein.

Dissection of the contribution of bushy cell delays to sound localization in juvenile and adult Mongolian gerbils

This study examines how delays in bushy cell axons contribute to sound localization in Mongolian gerbils, finding developmental changes in delay patterns and their impact on interaural time difference processing.

Nucleus accumbens acetylcholine dips track reward value and temporal costs to shape delay discounting

This study shows that nucleus accumbens acetylcholine dips track reward value and delay, influencing adaptive choice in mice during delay discounting tasks.

Feedback reliability modulates learning-related dynamics of midfrontal error monitoring

This study shows that feedback reliability affects midfrontal error monitoring dynamics during learning, with deterministic feedback leading to stronger neural responses than probabilistic feedback.

Human iEEG recordings during audiovisual speech violations support and extend predictive routing models

This study uses human iEEG recordings to test predictive routing models during audiovisual speech violations, finding support for gamma and alpha-beta oscillation interactions in predictive processing.

A Unified World Model in Human Posterior Parietal Cortex

The paper identifies the superior parietal lobule as a substrate for physical world modeling by showing neurons that predict physical events and encode intended hand actions.

Longitudinal persistence of EEG brain fingerprints: phase and complex coherency geometry across sessions and functional states

The paper evaluates geometric representations of EEG coherency for longitudinal individual identification across different functional states and timeframes.

Polyaxonal A1 amacrine cells form a spatially extended network in primate retina

The paper identifies and characterizes a long-range inhibitory circuit in primate retina involving A1 amacrine cells and recursive bistratified ganglion cells, revealing their network organization and spike dynamics.

When Tagging Frequency Matters to Attention: Effects on SSVEPs, ERPs, and Cognitive Processing

This study shows that tagging frequency affects neural responses and cognitive performance in attention tasks using SSVEPs and ERPs.

State-dependent modulation of cross-area sensory processing in mouse neocortex

The paper investigates how behavioral states modulate sensory processing across brain regions in mice during a choice task, identifying state-dependent differences in neural activity and information routing.

Neural and Gait Adaptations to Dual-Task Demands in Children and Young Adults: A Mobile Brain-Body Imaging (MoBI) Study.

This study examines how cognitive-motor interactions develop from childhood to young adulthood using dual-task paradigms and mobile brain-body imaging, finding age-related changes in neural and motor responses.

Flavonoid chronotherapy normalizes circadian dynamics and sleep architecture in mice with painful nerve injury

This study shows that flavonoids nobiletin and tangeretin restore circadian rhythms and improve sleep in mice with neuropathic pain.

Computational alternative to cardiac biopsy in multiple myeloma: utilizing the shape of routine laboratory data for the classification of AL cardiac amyloidosis

The paper develops machine learning models to classify AL cardiac amyloidosis in multiple myeloma patients using electronic medical records instead of cardiac biopsy.

Neural mechanisms for resilient sensory computation under metabolic stress

The paper investigates how food-restricted mice maintain visual discrimination performance by analyzing neural noise structure and decision time changes.

Bridging Sensory Extraction and Decision Dynamics: Face Pareidolia Emergent from Bottom-Up and Top-Down Interactions

This study investigates face pareidolia by analyzing EEG data during RSVP streams, showing that it results from both feedforward and top-down processes.

Rapid switching of in-phase and anti-phase interhemispheric rhythms within a single theta cycle: a mechanistic explanation

The paper explains how the granular retrosplenial cortex exhibits rapid switching between in-phase and anti-phase interhemispheric rhythms within a single theta cycle using computational models.

Quantitative spatial connectomics of liver reveals a partially exposed sympathetic network that integrates multiple cell types across the portal tract

The paper uses EM-based spatial connectomics to reveal the 3D structure of the mouse liver's sympathetic network, showing it is a meshwork with exposed varicosities and diverse cellular contacts.

Axonal spike-count regimes link spinal cord stimulation periodicity to artificial sensory detection and discrimination in rodents

This study links spinal cord stimulation periodicity to artificial sensory perception by identifying spike-count regimes that shape detection and discrimination behavior in rodents.

Combinatorial logic of Nav channels in nociceptor excitability: Different degrees of synergy define distinct neuronal groups

The paper investigates how combinations of Nav1.7 and Nav1.8 channels affect nociceptor excitability, showing that their synergistic effects vary across neuronal subtypes.

The Structural Basis of Genome Silencing: The Inactive X Chromosome Resolved by Electron Spectroscopic Imaging

This study uses Electron Spectroscopic Imaging to resolve the structural organization of the inactive X chromosome, revealing chromatin, RNA, and protein features in 3D.

Protein Scaffolds Modulate the Electronic Structure of a Common Ketyl Radical Intermediate in Thiamine Pyrophos-phate-Dependent Radical Biocatalysis: Insights from EPR and ENDOR Spectroscopy

This study uses EPR and ENDOR spectroscopy along with DFT to show how protein scaffolds alter the electronic structure of a ketyl radical intermediate in TPP-dependent radical biocatalysis, affecting enzyme reactivity.

Theta-Phase Targeted Encoding Gates Memory Sensitivity

This study investigates how theta-phase timing during encoding affects memory sensitivity using a closed-loop EEG system in an associative memory task.

Assessing whole-cortex excitability from electromagnetic brain signals

This study evaluates ten excitability metrics from MEG data to show cortical excitability is multidimensional with distinct spatial and functional patterns.

Oxytocin neurons signal state-dependent transitions from rest to thermogenesis and behavioral arousal in social and non-social settings

The paper shows PVNOT neurons drive transitions from rest to thermogenesis and behavioral arousal in both social and non-social contexts in mice.

Item-specific clustering of high gamma-band activity on theta phase during speech categorization

The paper investigates phase-dependent perceptual biases during speech categorization and finds item-specific theta-gamma phase-amplitude coupling linked to neural and perceptual responses.

Injectable Nanoparticles Assemble In Situ into Modular, Functionally Segmented Brain Electrodes

The paper develops injectable nanoparticles that form soft, functionally segmented brain electrodes capable of neuronal stimulation and gene transfer in chicken embryos.

Mesoscale Soft Robotics for Mechanically Perturbing and Functionally Monitoring Responses in Human Organoids

This paper introduces a mesoscale soft robotic interface to apply mechanical forces to human organoids and monitor their physiological responses, revealing distinct mechanical and electrophysiological behaviors in cortical and cardiac organoids.