Effects of early life stress on biochemical indicators of the dopaminergic system: a 3 level meta-analysis of rodent studies

Abstract

1. Introduction 1. Introduction 2. Materials and Methods 3. Results 4. Discussion 6 REFERENCES During the perinatal period, the brain matures and is rapidly wired(Semple et al. 2013), rendering it particularly vulnerable to negative life experiences that might lastingly impact brain function and behavior(Levine 2005). This may contribute to the well-established observation that exposure to adverse conditions during childhood is a major risk factor for the later development of psychopathologies(Teicher et al. 2016), including schizophrenia and substance abuse(Agid et al. 1999; Enoch 2011; Dube et al. 2003; Scheller-Gilkey et al. 2002).\n\nPrevailing evidence highlights that the dopamine (DA) system may ...