Author

Oliver David Howes

King's College LondonORCID 0000-0002-2928-1972Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 12 Organism:human· 11 Assay:imaging· 8 Research Focus:differential expression· 5 Assay:bulk RNA-seq· 4 Research Focus:cell-cell communication· 4 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

Matthew B. WalliD· 5 shared Mattia VeroneseiD· 4 shared Sridhar NatesaniD· 4 shared Ben K. StattoniD· 3 shared Ekaterina ShatalinaiD· 3 shared H. Valerie CurraniD· 3 shared Michael BloomfieldiD· 3 shared Tiago Reis MarquesiD· 3 shared

Activity by Year

2017-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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5 shared papersNeuroscience

Matthew B. WallORCID

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Author profile →

14 papers

Recent·Most cited

Reproducible Human Reward Imaging Phenotypes Exhibit Differential Sensitivity to Dopamine D2 Receptor Antagonism

Nicola Sambuco, Antonella Lupo, Peter C.T. Hawkins, Pierluigi Selvaggi, Linda Antonella Antonucci, Alessandro Bertolino, Giuseppe Blasi, Piergiuseppe Di Palo, Luigi Grassi, Daniela Grasso, Philipp Homan, Gian Marco Leggio, Francesco Massari, Alessio Maria Monteleone, Martin Osugo, , Giulio Pergola

The paper identifies two reproducible reward imaging phenotypes linked to dopamine D2 receptor function and shows differential responses to antipsychotic drugs.

Nature Communications · Sep 3, 2026Peer-reviewedNeuroscience

Cortical Iron in Schizophrenia: A Quantitative Susceptibility Mapping and Diffusion Tensor Imaging MRI Study

Luke James Vano, Jan Sedlacik, Stephen John Kaar, Grazia Rutigliano, Richard Carr, Alaine Berry, Ben K. Statton, Amir Fazlollahi, Oliver David Howes, Robert Ali McCutcheon

This study uses MRI to investigate cortical iron levels in schizophrenia patients and finds elevated iron in specific brain regions.

bioRxiv · Oct 17, 2025 · PreprintNeuroscience

Receptor-enriched analysis of functional connectivity (REACT) for understanding cannabinoid neuropsychopharmacology

Ekaterina Shatalina, Natalie Ertl, Kat Petrilli, Shelan Ofori, Anna Borissova, Claire Mokrysz, H. Valerie Curran, Will Lawn, Tom P. Freeman, Oliver David Howes, Matthew B. Wall

This study investigates how THC and CBD affect CB1 and CB2 receptor-enriched functional connectivity using REACT analysis in cannabis users.

bioRxiv · Jun 2, 2025 · PreprintNeuroscience

The relationship between brain activation and mitochondrial complex I protein levels during cognitive function in healthy humans: an BCPP-EF PET and functional MRI study of task switching

Ekaterina Shatalina, Thomas Whitehurst, Ellis Chika Onwordi, Alex Whittington, Ayla Mansur, Atheeshaan Arumuham, Tiago Reis Marques, Roger N. Gunn, Sridhar Natesan, Matthew M. Nour, Eugenii A. Rabiner, Matthew B. Wall, Oliver David Howes

This study links mitochondrial complex I levels to task switching performance and BOLD response using PET and fMRI in healthy humans.

bioRxiv · Sep 25, 2024 · PreprintNeuroscience

Spontaneous brain activity and synaptic density in schizophrenia: a combined UCB-J PET and fMRI study

Ekaterina Shatalina, Ellis Chika Onwordi, Thomas Whitehurst, Alex Whittington, Ayla Mansur, Atheeshaan Arumuham, Tiago Reis Marques, Roger N. Gunn, Sridhar Natesan, Eugenii A. Rabiner, Matthew B. Wall, Oliver David Howes

This study investigates the relationship between spontaneous brain activity (ALFF) and presynaptic density (measured by [11C]UCB-J PET) in schizophrenia, finding group differences in their correlation.

bioRxiv · Sep 25, 2024 · PreprintNeuroscience

Transcriptional and neurochemical signatures of cerebral blood flow alterations in schizophrenia and the clinical high-risk state for psychosis

Samuel Knight, Leyla Abbasova, Yashar Zeighami, Justine Y. Hansen, Daniel Martins, Fernando O. Zelaya, Ottavia Dipasquale, T. Liu, D. Shin, Matthijs Geert Bossong, Matilda Azis, Mathilde Antoniades, Oliver David Howes, Ilaria Bonoldi, Alice Egerton, , Gemma Modinos

The paper identifies cellular and neurochemical signatures associated with cerebral blood flow alterations in schizophrenia and clinical high-risk states using combined neuroimaging and transcriptomic data.

bioRxiv · Mar 13, 2024 · PreprintNeuroscience

Dopamine and schizophrenia from bench to bedside: Discovery of a striatal co-expression risk gene set that predicts in vivo measures of striatal function.

Leonardo Sportelli, Daniel Paul Eisenberg, Roberta Passiatore, Enrico D’Ambrosio, Linda Antonella Antonucci, Qiang Chen, Jasmine Czarapata, Aaron L. Goldman, Michael A. Gregory, Kira Griffiths, Thomas M. Hyde, Joel E. Kleinman, Antonio F. Pardiñas, Madhur Parihar, Teresa Popolizio, , Giulio Pergola

The paper identifies a striatal gene set linked to schizophrenia risk that predicts in vivo dopamine synthesis and striatal activation in neurotypical and patient cohorts.

bioRxiv · Sep 20, 2023 · PreprintNeuroscience

Mapping neuroinflammation in vivo with diffusion-MRI in rats given a systemic lipopolysaccharide challenge

Eugene Kim, Inês Figueiredo, Camilla Simmons, Karen Randall, Loreto Rojo Gonzalez, Tobias Wood, Brigida Ranieri, Paula Sureda-Gibert, Oliver David Howes, Carmine Maria Pariante, Ofer Pasternak, Flavio Dell’Acqua, Federico Turkheimer, Diana Cash

This study uses diffusion MRI to detect neuroinflammation in vivo in rats after a lipopolysaccharide challenge, showing diffusivity changes correlate with microglial morphology.

bioRxiv · Nov 22, 2022 · PreprintNeuroscience

The acute effects of cannabidiol on emotional processing and anxiety: a neurocognitive imaging study

Michael Bloomfield, Yumeya Yamamori, Chandni Hindocha, A. Jones, Jocelyn LL Yim, Hannah R Walker, Ben K. Statton, Matthew B. Wall, Rachel Lees, Oliver David Howes, Valerie H. Curran, Jonathan Paul Roiser, Tom P. Freeman

This study investigates the acute effects of CBD on emotional processing and anxiety using neuroimaging and cognitive measures, finding no significant effects compared to placebo.

Psychopharmacology · Apr 21, 2022Peer-reviewedNeuroscience

Individual and combined effects of Cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) on striato-cortical connectivity in the human brain

Matthew B. Wall, Tom P. Freeman, Chandni Hindocha, Lysia Demetriou, Natalie Ertl, Abigail M. Freeman, A. Jones, Will Lawn, Rebecca Anne Pope, Claire Mokrysz, Daniel Solomons, Ben K. Statton, Hannah R Walker, Yumeya Yamamori, Zixu Yang, , Michael Bloomfield

This study examines how CBD and THC affect striato-cortical connectivity in the human brain using fMRI, finding THC disrupts connectivity while CBD mitigates some effects and has mixed impacts when used alone.

bioRxiv · Nov 20, 2020 · PreprintNeuroscience

Links between central CB1-receptor availability and peripheral endocannabinoids in patients with first episode psychosis

Alex M. Dickens, Faith Borgan, Heikki Laurikainen, Santosh Lamichhane, Tiago Reis Marques, Tuukka Rönkkö, Mattia Veronese, Tuomas Lindeman, METSY Investigators, Tuulia Hyötyläinen, Oliver David Howes, Jarmo A. Hietala, Matej Orešič

The paper investigates the relationship between central CB1-receptor availability and peripheral endocannabinoids in first-episode psychosis patients and healthy controls, finding dysregulated cross-talk between these systems.

Schizophrenia · Aug 26, 2020Peer-reviewedNeuroscience

Contrasting effects of chronic lithium, haloperidol and olanzapine exposure on synaptic clusters in the rat prefrontal cortex

Els F. Halff, Marie-Caroline Côtel, Sridhar Natesan, Richard McQuade, Chris J. Ottley, Deepak P. Srivastiva, Oliver David Howes, Anthony Christopher Vernon

This study examines the effects of chronic lithium, haloperidol, and olanzapine on synaptic markers in rat prefrontal cortex, finding lithium increases NLGN clusters while antipsychotics have no effect.

bioRxiv · Apr 14, 2020 · PreprintNeuroscience

Mesocorticolimbic circuit mechanisms underlying the effects of ketamine on dopamine: a translational imaging study

Michelle Kokkinou, Elaine E. Irvine, David R. Bonsall, Sridhar Natesan, Lisa A. Wells, Mark Smith, Justyna A. Glegola, Eleanor J. Paul, Kyoko Tossell, Mattia Veronese, Sanjay P. Khadayate, Nina Dedic, Seth C. Hopkins, Mark A. Ungless, Dominic J. Withers, Oliver David Howes

This study shows that sub-chronic ketamine in mice increases striatal dopamine synthesis and locomotor activity, which can be reversed by targeting PV interneurons and TAAR1.

bioRxiv · Sep 1, 2019 · PreprintNeuroscience

The Effect Of Perinatal Brain Injury On Dopaminergic Function And Hippocampal Volume In Adult Life

Seán Froudist‐Walsh, Michael Bloomfield, Mattia Veronese, Jasmin Kroll, Vyacheslav R. Karolis, Sameer Jauhar, Ilaria Bonoldi, Philip K. McGuire, Shitij Kapur, Robin M. Murray, Chiara Nosarti, Oliver David Howes

This study finds that perinatal brain injury in very preterm humans is linked to reduced dopamine synthesis and hippocampal volume in adulthood.

eLife · Nov 27, 2017Peer-reviewedNeuroscience