mSystemsBioinformaticsPeer-reviewed journal article
Rationally Minimizing Natural Product Libraries Using Mass Spectrometry
Monica Ness, Thilini PeramunaiD, Karen L. Wendt, Jennifer E. CollinsiD, Jarrod B. King, Raphaella PaesiD, Natalia Mojica SantosiD, Crystal Okeke, Cameron R. Miller, Debopam ChakrabartiiD, Robert H. CichewicziD, Laura‐Isobel McCalliD
Abstract
Natural product libraries are crucial to drug development, but large libraries drastically increase the time and cost during initial high throughput screens. Here, we developed a method that leverages liquid chromatography-tandem mass spectrometry spectral similarity to dramatically reduce library size, with minimal bioactive loss. This method offers a broadly applicable strategy for accelerated drug discovery with cost reductions, which enable implementation in resource-limited settings.
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- top 10%
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