Stimulus novelty uncovers coding diversity in survey of visual cortex

Marina Garrett; Peter A. Groblewski; Alex T. Piet; Douglas R. Ollerenshaw; Farzaneh Najafi; Iryna Yavorska; Adam Amster; Corbett Bennett; Michael A. Buice; Shiella Caldejon; Linzy Casal; Florence D. D’Orazi; Scott F. Daniel; Saskia E. J. de Vries; Daniel Kapner; Justin T. Kiggins; Jérôme A. Lecoq; Peter Ledochowitsch; Sahar Manavi; Nicholas J. Mei; Christopher B. Morrison; Sarah A. Naylor; Natalia Orlova; Jed Perkins; Nick Ponvert; Clark Roll; Sam Seid; Derric Williams; Allison Williford; Ruweida Ahmed

doi:10.1101/2023.02.14.528085

NeurosciencebioRxivFeb 14, 2023

Preprint

Stimulus novelty uncovers coding diversity in survey of visual cortex

Marina Garrett iD, Peter A. Groblewski iD, Alex T. Piet iD, Douglas R. Ollerenshaw iD, Farzaneh Najafi iD, Iryna Yavorska, Adam Amster iD, Corbett Bennett iD, Michael A. Buice iD, Shiella Caldejon iD, Linzy Casal, Florence D. D’Orazi iD, Scott F. Daniel iD, Saskia E. J. de Vries iD, Daniel Kapner, Justin T. Kiggins iD, Jérôme A. Lecoq iD, Peter Ledochowitsch iD, Sahar Manavi iD, Nicholas J. Mei iD, Christopher B. Morrison iD, Sarah A. Naylor iD, Natalia Orlova iD, Jed Perkins, Nick Ponvert, , Shawn R. Olsen iD

Abstract

Detecting novel stimuli in the environment is critical for learning and survival, yet the neural basis of novelty processing is not understood. To characterize cell type-specific novelty processing, we surveyed the activity of [~]15,000 excitatory and inhibitory neurons in mice performing a visual task with novel and familiar stimuli. Clustering revealed a dozen functional neuron types defined by experience-dependent encoding. Vasoactive-intestinal-peptide (Vip) expressing inhibitory neurons were diverse, encoding novel stimuli, omissions of familiar stimuli, or behavioral features. Distinct Somatostatin (Sst) expressing inhibitory neurons encoded either familiar or novel stimuli. Subsets of excitatory neurons co-clustered with specific Vip or Sst subpopulations, while Sst and Vip inhibitory clusters were non-overlapping. This study establishes that novelty processing is mediated by diverse functional neuron types in the visual cortex.

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