MONET: Multi-omic patient module detection by omic selection

Abstract

Recent advances in experimental biology allow creation of datasets where several genome-wide data types (called omics) are measured per sample. Integrative analysis of multi-omic datasets in general, and clustering of samples in such datasets specifically, can improve our understanding of biological processes and discover different disease subtypes. In this work we present Monet (Multi Omic clustering by Non-Exhaustive Types), which presents a unique approach to multi-omic clustering. Monet discovers modules of similar samples, such that each module is allowed to have a clustering structure for only a subset of the omics. This approach differs from most extant multi-omic clustering algorithms, which assume a common structure across all omics, and from several recent algorithms that model distinct cluster structures using Bayesian statistics. We tested Monet extensively on simulated data, on an image dataset, and on ten multi-omic cancer datasets from TCGA. Our analysis shows that Monet compares favorably with other multi-omic clustering methods. We demonstrate Monets biological and clinical relevance by analyzing its results for Ovarian Serous Cystadenocarcinoma. We also show that Monet is robust to missing data, can cluster genes in multi-omic dataset, and reveal modules of cell types in single-cell multi-omic data. Our work shows that Monet is a valuable tool that can provide complementary results to those provided by extant algorithms for multi-omic analysis.