Correlated structure of neuronal firing in macaque visual cortex limits information for binocular depth discrimination

Abstract

Variability in cortical neural activity potentially limits sensory discriminations. Theoretical work shows that information required to discriminate two similar stimuli is limited by the correlation structure of cortical variability. We investigated these information-limiting correlations by recording simultaneously from visual cortical areas V1 and V4 in macaque monkeys, performing a binocular, stereo-depth discrimination task. Within both areas, noise correlations on a rapid temporal scale (20-30ms) were stronger for neuron-pairs with similar selectivity for binocular depth, meaning that these correlations potentially limit information for making the discrimination. Between-area correlations (V1 to V4) were different, being weaker for neuron pairs with similar tuning, and having a slower temporal scale (100+ms). Fluctuations in these information-limiting correlations just prior to the detection event were associated with changes in behavioural accuracy. Although these correlations limit the recovery of information about sensory targets, their impact may be curtailed by integrative processing of signals across multiple brain areas.