GAS Power Calculator: web-based power calculator for genetic association studies
Abstract
MotivationStatistical power calculations are crucial in designing genetic association studies. They help guide tradeoffs between large sample sizes and detailed assessments of genotype and phenotype, help determine which studies are viable, and help interpret research findings. To facilitate widespread use of power analysis in the design and interpretation of genetic studies, it is important to enable users to calculate power and visualize the effect of different models and design choices in convenient, interactive tools that are easily accessible.\n\nResultsWe developed the Genetic Association Study (GAS) Power Calculator to provide users with a simple interface that can be compute the power of genetic association studies in a convenient browser based interface.\n\nAvailabilityThe GAS Power Calculator can be accessed from the web interface at http://csg.sph.umich.edu/abecasis/gas_power_calculator/. Source code is available at https://github.com/jenlij/GAS-power-calculator.
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Abstract summary
Claude Opus 5.5 · xhigh effort · 18 Oct 2026 · from the abstract
Compute the power of a genetic association study in a simple browser interface; both the hosted calculator and its source code are publicly available.
Power calculations guide the trade-off between large samples and detailed genotype and phenotype assessment, decide which studies are viable, and shape how findings are read. The argument here is that wider use of power analysis needs convenient, interactive tools in which users can calculate power and see the effect of different models and design choices.
Key results
ClaimedThe GAS Power Calculator computes power for genetic association studies through a simple interface that runs in a web browser.
Announced in the results part of the abstract; no benchmark against analytic power calculations, no worked example and no comparison with existing power tools is reported. · Abstract
ClaimedThe tool is openly available: a hosted web interface plus a public source repository.
Both addresses are printed in the availability statement, the interface at csg.sph.umich.edu and the source on GitHub; the abstract says nothing about licence, versioning or dependencies. · Abstract
Methods, data and reproducibility
A web application, the GAS Power Calculator, that computes statistical power for genetic association studies through a simple browser interface; the abstract does not describe the underlying model, the parameters it takes or how results are presented.
- Methods & tools
- GAS Power Calculator
Limitations (2)
- The abstract names no statistical models, study designs or genetic parameters the calculator supports, so its coverage, for example case-control versus quantitative traits or allele-frequency assumptions, cannot be judged from the text. · noted in this summary
- No validation against analytic or simulation-based power estimates is reported, and no comparison is made with existing power calculators. · noted in this summary
Who should read:Read this if you are sizing a genetic association study and want a browser-based power calculator you can open instead of writing the calculation yourself.
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