Development of functional corticomuscular connectivity from childhood to adulthood during precision grip with the dominant and non-dominant hand

Abstract

How does the neural control of manual movements mature from childhood to adulthood? Here, we investigated developmental differences in functional corticomuscular connectivity using coherence techniques in 91 individuals recruited from four different age groups covering the age range 8-30y. EEG and EMG were recorded while participants performed a unimanual visual force-tracing task requiring fine control of the force produced in a precision grip with both the dominant and non-dominant hand. Using beamforming methods, we reconstructed source activity from EEG data displaying peak coherence with the active FDI muscle during the task in order to assess functional corticomuscular connectivity. Our results revealed that coherence was greater in adolescents and adults than in children and that the difference in coherence between children and adults was driven by a greater magnitude of descending (cortex-to-muscle) coherence. This was paralleled by the observation of a posterior-to-anterior shift in the cortical sources displaying corticomuscular coherence within the contralateral hemisphere from late adolescence. Finally, we observed that corticomuscular coherence was higher on the non-dominant compared to the dominant hand across age groups. These findings provide a detailed characterization of differences in task-related corticomuscular connectivity for individuals at different stages of typical ontogenetic development that may be related to the maturational refinement of dexterous motor control. Key points- Fine motor control is gradually refined during human motor development, but little is known about the underlying neurophysiological mechanisms. - Here, we used EEG and EMG to investigate functional corticomuscular connectivity during a precision grip with the dominant and non-dominant hand in 91 typically developed children, adolescents and adults (age range 8-30y). - We show that older adolescents and adults are characterized by greater levels of corticomuscular coherence compared to children and that this is mainly driven by greater magnitudes of descending coherence (cortex-to-muscle). This is paralleled by a more anterior cortical site of coherence in older adolescents and adults compared to younger individuals. - These results help us better understand the ontogenetic development of task-related functional connectivity in sensorimotor networks.