In-vivo Therapeutic Evaluation of the Wound Healing: Potential of Ethanolic Extract of Trichilia heudelotii Leaves in Wistar Rats

Abstract

BackgroundTrichilia heudelotii belongs to the Meliaceae family and is commonly used in indigenous African medicine to prevent and treat various microbial ailments. MethodsTrichilia heudelotiis ethanolic leaf extracts contains phytochemicals which was studied to demonstrate its wound-healing properties. Phytochemical screening of leaf extracts contains flavonoids, phenolics, tannins, terpenoids, saponins, and alkaloids, which play a vital part in the healing process. Overall, quantitative, and qualitative screening were performed to evaluate the therapeutic efficacy of Trichilia heudelotiis phytochemicals for wound treatment. ResultsThe wound-healing potency was evaluated using different concentrations of formulated oil extracts (0.5, 1.0, and 2.0g/10g) on fresh wounds inflicted on Wistar rats using the excision model. Healing capacity was assessed based on rate of wound contracting ability, time of wound closure, and epithelisation period. The results shows that leaf extract oils exhibited significant wound healing capacity (p View larger version (34K): org.highwire.dtl.DTLVardef@18dbe8corg.highwire.dtl.DTLVardef@d8eb90org.highwire.dtl.DTLVardef@15152f7org.highwire.dtl.DTLVardef@1de83e_HPS_FORMAT_FIGEXP M_FIG C_FIG