medRxivGenetic & Genomic MedicinePreprint
The Effects of Mindfulness Meditation on Burnout in Clinical Genetic Counselors: A Three-Arm Randomized Controlled Trial
Colleen A. CaleshuiD, MaryAnn W. CampioniD, Jehannine AustiniD, Philippe R. GoldiniD, Julia Silver, Aad TibbeniD
Abstract
Burnout is common among genetic counselors (GCs). Clinician burnout has been found to adversely affect individual well-being, patient care, and likelihood of staying in a role. Both individual and systems solutions are needed to address clinician burnout. Mindfulness meditation (MM) is one individual-level solution that has shown promise for reducing burnout in other clinicians but has not been studied in GCs. We conducted a decentralized, parallel, three-arm randomized controlled trial comparing MM to a novel active control meditation (ACM) and a no-meditation control (NMC), with 1:1:1 randomization. Participants were clinical GCs in the US. MM and ACM participants were asked to do 10 minutes of daily app-based meditation for 8 weeks. ACM was designed to control for non-specific aspects of MM by mimicking MM length and structure without including mindfulness techniques. The primary outcome, burnout, was assessed using the Professional Fulfillment Index. Secondary outcomes included other indicators of professional well-being, such as stress and professional fulfillment. Outcomes were assessed via an intention-to-treat approach, with multiple imputation for missing outcome data. Outcome analyses controlled for baseline trait mindfulness. 397 participants (mean age 33 years; 97.7% female, 94.2% White) were randomized, and 76% completed post-intervention outcome measures. There was no difference in burnout reduction between MM and ACM groups (p = 0.44). However, multiple measures suggest that ACM did not perform well as an inert active meditation control, thus the primary hypothesis could not be effectively tested. In pre-planned secondary analyses, MM reduced burnout (Cohens d = -0.84, p < 0.001) compared to NMC, a passive control. Similar results were seen for stress. These findings suggest MM may be beneficial for GC professional well-being; however, further research on MM for GCs is needed with more diverse study samples and better active controls.
- Citations
- 0
Reproducibility ledger
Nobody has reported trying to reproduce this paper yet. Did you replicate an experiment or run the code? Your report saves the next lab a week.
Sign in to file a reproducibility report.
Related papers
- Well-being and self-care strategies for cardiovascular genetic counselors: a qualitative study
Laura Yeates, Lucas A. Mitchell, … Jodie Ingles·Journal of Genetic CounselingPeer-reviewed·Sep 15, 2025
- Ambient AI Documentation in Clinical Genetics: Perspectives on Implementation and Impact on Burnout
Anjali Narain, Jason M. Misurac, … Colleen A. Campbell·medRxiv·Jul 2, 2026
- Contemplative mental training reduces hair glucocorticoid levels in a randomized clinical trial
Lara M. C. Puhlmann, Pascal Vrtička, … Tania Singer·Psychosomatic MedicinePeer-reviewed·Jul 9, 2021
- Navigating the Impact of the 21st Century Cures Act Final Rule: A National Cross-Sectional Survey of U.S. Genetic Counselors
Chenery L. Lowe, Laura Duncan, … Debra Mathews·Journal of Genetic CounselingPeer-reviewed·May 12, 2025
- Cardiovascular genetic counseling is associated with improved patient-reported outcomes across clinical indications and settings
Brittney A. Murray, Catherine Gordon, … Cynthia A. James·Circulation Genomic and Precision MedicinePeer-reviewed·Oct 1, 2026
- Facing the waves of negative mood: Trait mindfulness moderates the links between physiology and emotion
Ashley Michelle Campos, Gayathri Batchalli Maruthy, … Bart Rypma·bioRxiv·Nov 3, 2026