Global Parkinson's Genetics Program (GP2) Complex Network Protocol: Defining the causes of sporadic Parkinson's disease

Clodagh Towns; Madeleine Richer; Simona Jasaityte; Eleanor J. Stafford; Julie Joubert; Tarek Antar; Alejandro Martínez-Carrasco; Mary B. Makarious; Bradford H. Casey; Dan Vitale; Kristin S. Levine; Hampton L. Leonard; Caroline B. Pantazis; Laurel A. Screven; Dena G. Hernandez; Claire Wegel; Justin Cook Solle; Mike A. Nalls; Cornelis Blauwendraat; Andrew Singleton; Manuela M. X. Tan; Hirotaka Iwaki; Huw R. Morris; the Global Parkinson’s Genetics Program (GP2); Emilia Mabel Gatto; Marcelo  Andrés Kauffman; Samson G. Khachatryan; Zaruhi D. Tavadyan; Claire E. Shepherd; Julie Hunter

doi:10.1038/s41531-023-00533-w

Genetic & Genomic Medicinenpj Parkinson s DiseaseSep 12, 2023

Peer-reviewed journal article

Global Parkinson's Genetics Program (GP2) Complex Network Protocol: Defining the causes of sporadic Parkinson's disease

Clodagh Towns iD, Madeleine Richer iD, Simona Jasaityte iD, Eleanor J. Stafford iD, Julie Joubert, Tarek Antar iD, Alejandro Martínez-Carrasco iD, Mary B. Makarious iD, Bradford H. Casey iD, Dan Vitale iD, Kristin S. Levine iD, Hampton L. Leonard iD, Caroline B. Pantazis iD, Laurel A. Screven iD, Dena G. Hernandez iD, Claire Wegel, Justin Cook Solle iD, Mike A. Nalls iD, Cornelis Blauwendraat iD, Andrew Singleton iD, Manuela M. X. Tan iD, Hirotaka Iwaki iD, Huw R. Morris iD, the Global Parkinson’s Genetics Program (GP2), Emilia Mabel Gatto iD, , Andrea Quattrone iD

Abstract

The Global Parkinsons Genetics Program (GP2) will genotype over 150,000 participants from around the world, and integrate genetic and clinical data for use in large-scale analyses to dramatically expand our understanding of the genetic architecture of PD. This report details the workflow for cohort integration into the complex arm of GP2, and together with our outline of the monogenic hub in a companion paper, provides a generalizable blueprint for establishing large scale collaborative research consortia.

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