The amblyopic acuity deficit: impact on the identification of letters distorted by spatial scrambling algorithms

Abstract

The letter acuity impairment in the amblyopic eye often exceeds predictions made from the cut-off spatial frequency for grating detection. Spatial scrambling in the amblyopic eyes projections to the visual cortex has been proposed to bear some responsibility for this additional deficit. Using a novel stimulus algorithm that creates spatially scrambled bandpass letters, we generated stimuli simulating either: i) "cortical scrambling" at the output of oriented model "simple cells", or ii) "subcortical scrambling" of isotropic subunits that combine to form these simple cells. We also investigated a more conventional "noise masking" with bandpass noise. We performed two bandpass letter identification experiments, equating the stimuli shown to each eye by normalising either: i) their contrast, presenting them at four times their contrast detection threshold; or ii) their spatial scale, presenting them at twice the participants acuity threshold for each eye. At the group level, we found that the amblyopic eye is less efficient at performing letter identification in bandpass noise. We did not find an overall significant difference with either scrambling type when comparing efficiency between the amblyopic and fellow eye, but we did find such a difference when partitioning our participants by their stereopsis ability. In further analyses of the pattern of mistakes, we found the amblyopic eye shows a distinctive behaviour which correlates with the acuity deficit for both types of scrambling. These results demonstrate that our scrambled stimuli interrogate a component of amblyopic vision that is functionally distinct from that addressed by contrast noise masking.