bioRxivCancer Biology
CIViC: A knowledgebase for expert-crowdsourcing the clinical interpretation of variants in cancer.
Malachi GriffithiD, Nicholas C Spies, Kilannin KrysiakiD, Adam C Coffman, Joshua F McMichael, Benjamin J Ainscough, Damian T Rieke, Arpad M Danos, Lynzey KujaniD, Cody A Ramirez, Alex H Wagner, Zachary L Skidmore, Connor J Liu, Martin R Jones, Rachel L Bilski, Robert Lesurf, Erica K Barnell, Nakul M Shah, Melika BonakdariD, Lee TraniiD, Matthew Matlock, Avinash RamuiD, Katie M Campbell, Gregory C Spies, Aaron P Graubert, , Elaine R Mardis
Abstract
CIViC is an expert crowdsourced knowledgebase for Clinical Interpretation of Variants in Cancer (www.civicdb.org) describing the therapeutic, prognostic, and diagnostic relevance of inherited and somatic variants of all types. CIViC is committed to open source code, open access content, public application programming interfaces (APIs), and provenance of supporting evidence to allow for the transparent creation of current and accurate variant interpretations for use in cancer precision medicine.
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