Elevated body mass index in youth is associated with dysregulated surrogate markers of neural inhibition & excitation, and internetwork functional dysconnectivity

Abstract

The developing child and adolescent brain is thought to have an increased vulnerability to the negative impact of obesity and excessive consumption of hyperpalatable and energy-rich foods. In this study, we investigated the neurophysiological effects of overweight and obesity in 30 participants spanning childhood and adolescence (8-19 years), using a naturalistic viewing paradigm with Inscapes, in a pseudo-resting-state protocol scan with magnetoencephalography (MEG). Subjects were median split on body mass indices (BMI), categorised into two groups comprising: lower <25 kg/m2 (n=15) and higher [≥]25 kg/m2 (n=15). We assessed spontaneous, regional neural function indexed by oscillatory activity, and functional connectivity within and between intrinsic resting brain networks, including the default mode network, dorsal and ventral attention, somatomotor, visual, language, central executive and salience networks. Elevated BMI was associated with significant reductions in activity of the posterior dominant rhythm, and gamma hyperactivity across widespread cortical areas, suggesting intrinsic neuronal hyperexcitability and disinhibition in children and adolescents. Additionally, we observed low-frequency theta hypoconnectivity between resting state networks including the salience, visual, and default mode networks, and overall reduced global efficiency in brain network structure, suggesting reduced effectiveness in neural communication. These findings underscore the neural impact of body composition on the developing brain, suggesting deleterious alterations in excitation and inhibition from surrogate neural markers associated with neurochemistry and brain networks linked with cognitive and behavioural functioning. These alterations may contribute to the persistent behavioural rigidity and difficulties in adopting healthier eating behaviours into adulthood.