E. Martin

Adiposity in Adolescence has Detrimental Effects on Developing Brain Structures and Organization, Communication, and Controllability of Resting-State Networks

This study examines how adolescent adiposity affects brain structure and network organization, finding associations with weaker neural networks and altered brain morphology.

The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate

The paper shows that the nuclear periphery represses H3K9me2-marked genes and transposons, and its loss disrupts cell fate transitions in mESCs.

A system for functional studies of the major virulence factor of malaria parasites

The paper develops a system to study PfEMP1, a key malaria parasite virulence factor, by generating parasites expressing a single PfEMP1 variant and enabling genome edits to investigate its function.

Latitudinal gradients in predation persist in urban environments

The paper tests if urbanization disrupts latitudinal gradients in seed predation across 14,000 km of latitude, finding that gradients persist despite habitat modification.

Establishment and comparative genomics of a high-quality collection of mosquito-associated bacterial isolates -- MosAIC (Mosquito-Associated Isolate Collection)

The paper establishes a high-quality bacterial isolate collection (MosAIC) from mosquitoes, providing genomic data and phylogenomic analysis to study mosquito-associated bacteria.

Capture of circulating metastatic cancer cell clusters from a lung cancer patient can reveal a unique genomic profile and potential anti-metastatic molecular targets: A proof of concept study.

This study captures metastatic cancer cell clusters from lung cancer patients and identifies their unique genomic profiles and potential anti-metastatic targets.

Deleterious functional consequences of perfluoroalkyl substances accumulation into the myelin sheath

This study shows that PFOS exposure disrupts oligodendrogenesis and myelin function, impairing remyelination and potentially contributing to myelin disorders like multiple sclerosis.

Differential roles of CTP synthetases CTPS1 and CTPS2 in cell proliferation

The paper investigates the differential roles of CTPS1 and CTPS2 in cell proliferation, finding that CTPS1 is more critical for cell growth than CTPS2.

Time-resolved proximity proteomics uncovers a membrane tension-sensitive caveolin-1 interactome at the rear of migrating cells

This study identifies a membrane tension-sensitive caveolin-1 interactome at the rear of migrating cells using proximity proteomics and mass spectrometry.

Prefrontal accumbens neural dynamics abnormalities in mice vulnerable to develop food addiction

This study identifies disrupted mPFC-NAc neural dynamics in mice with food addiction, showing that rimonabant restores these abnormalities.

Variation in diet and microbial exposure shape the performance of the Asian tiger mosquito, Aedes albopictus

This study investigates how diet and microbial exposure affect the performance of the Asian tiger mosquito, showing their complex interactions influence survival and development.

Complementary CRISPR screen highlights the contrasting role of membrane-bound and soluble ICAM-1 in regulating antigen specific tumor cell killing by cytotoxic T cells

The paper uses a complementary CRISPR screen to identify genes regulating tumor resistance to CTL killing, revealing contrasting roles of membrane-bound and soluble ICAM-1.

A tumour-promoting senescent secretome triggered by platinum chemotherapy exploits a targetable TGFβR1/Akt-mTOR axis in lung cancer

This study shows platinum chemotherapy induces a senescent secretome in lung cancer that promotes tumor growth via the TGFβR1/Akt-mTOR axis, and targeting this pathway reduces tumor burden.

De-novo generation of novel phenotypically active molecules for Chagas disease from biological signatures using AI-driven generative chemistry

This paper uses AI-driven generative chemistry to design a novel molecule active against Chagas disease parasites, validated experimentally.

Lowland ecotype Cyperus rotundus L. affects growth and yield of rice under flooded conditions in the Philippines

This study examines the impact of lowland ecotype Cyperus rotundus on rice growth and yield under flooded conditions in the Philippines, finding reduced rice productivity with increasing weed density.

The effects of host availability and fitness on Aedes albopictus blood feeding patterns in New York

This study examines Ae. albopictus blood feeding patterns in New York, finding that cats and dogs are disproportionately fed upon compared to humans, with no significant fitness differences among hosts.

Chromatin Accessibility Maps Provide Evidence of Multilineage Gene Priming in Hematopoietic Stem Cells

The paper uses ATAC-seq to compare chromatin accessibility in hematopoietic stem cells with unipotent cell types, finding evidence of lineage-specific cis element priming and differences in accessibility patterns.

CD28 costimulatory domain protects against tonic signaling-induced functional impairment in CAR-Tregs

This study compares CD28 and 4-1BB costimulatory domains in CAR-Tregs, finding CD28 better preserves function and survival under tonic signaling.

Integrating multiple experimental data to determine conformational ensembles of an intrinsically disordered protein

The paper integrates NMR, SAXS, and smFRET data to determine the conformational ensembles of Sic1 and pSic1, showing consistency across methods and validating their structural models.

Modulation of T helper 1 and T helper 2 immune balance in a stress mouse model during Chlamydia muridarum genital infection

This study shows cold-induced stress modulates Th1/Th2 balance in mice infected with Chlamydia muridarum by increasing Th2 cytokines and decreasing Th1 cytokines.

Evaluation of deacetylase inhibition in metaplastic breast carcinoma using multiple derivations of preclinical models of a new patient-derived tumor

This study evaluates deacetylase inhibitors in metaplastic breast carcinoma using multiple preclinical models, finding they reduce metastasis and synergize with chemotherapy.

Network Analysis Of Inflammatory Bowel Disease Reveals PTPN2 As New Monogenic Cause Of Intestinal Inflammation

The paper uses network analysis to identify PTPN2 as a new monogenic cause of intestinal inflammation by integrating monogenic and polygenic IBD data.

SIZ1 is a nuclear host target of the nematode effector GpRbp1 from Globodera pallida that acts as a negative regulator of basal plant defense to cyst nematodes

This paper identifies SIZ1 as a target of the nematode effector GpRbp-1, showing it modulates plant defense and susceptibility to cyst nematodes.

DNA replication initiation in Bacillus subtilis; Structural and functional characterisation of the essential DnaA-DnaD interaction

This study characterizes the DnaA-DnaD interaction in Bacillus subtilis using NMR and single-molecule FRET, revealing structural details and functional roles in DNA replication initiation.