When shared concept cells support associations: theory of overlapping memory engrams

Assemblies of neurons, called concepts cells, encode acquired concepts in human Medial Temporal Lobe. Those concept cells that are shared between two assemblies have been hypothesized to encode associations between concepts. Here we test this hypothesis in a computational model of attractor neural networks. We find that for concepts encoded in sparse neural assemblies there is a minimal fraction cmin of neurons shared between assemblies below which associations cannot be reliably implemented; and a maximal fraction cmax of shared neurons above which single concepts can no longer be retrieved. In the presence of a periodically modulated background signal, such as hippocampal oscillations, recall takes the form of association chains reminiscent of those postulated by theories of free recall of words. Predictions of an iterative overlap-generating model match experimental data on the number of concepts to which a neuron responds. Authors contributionsAll authors contributed to conception of the study and writing of the manuscript. CG and TS developed the theory. CG wrote the code for all figures. EDF and RQQ provided the experimental data. EDF and CG analyzed the data. WG and CG developed algorithms to fit the experimental data.