npj Digital MedicineBioinformaticsPeer-reviewed journal article
Cross-Platform Omics Prediction procedure enables precision medicine in patients with stage-III melanoma
Kevin Y. X. WangiD, Gulietta M. PupoiD, Varsha Tembe, Ellis PatrickiD, Dario StrbenaciD, Sarah‐Jane SchrammiD, John F. ThompsoniD, Richard A. ScolyeriD, Samuel MülleriD, Garth TarriD, Graham J. ManniD, Jean Yee Hwa YangiD
Abstract
There is no consensus methodology that can account for the variation in omics signatures when they are acquired across different platforms and times. This poses a significant barrier to the implementation of valuable biomarkers into clinical practice. We present a novel procedure (Cross-Platform Omics Prediction) that accounts for these variations and demonstrate its utility in three risk models for different diseases that is suitable for prospective and multi-centre clinical implementation.
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- 7
- FWCI
- 0.57
- Field percentile
- top 43%
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