The paper improves metabolomic biomarker discovery in admixed American cohorts by training models on diverse data, achieving better predictive performance and more significant associations with cardiometabolic diseases.

medRxiv · Sep 7, 2026 · PreprintGenetic & Genomic Medicine

OmicsPred as a centralised resource for genetic prediction of multi-omic traits

Carles Foguet, Laurent Gil, Yu Xu, Sofia Salazar-Magaña, Scott C. Ritchie, Elodie Persyn, Hae Kyung Im, Michael Inouye, Samuel A. Lambert

OmicsPred collects 3,339,469 genetic prediction models for transcript, protein and metabolite traits with harmonised metadata and MetaXcan/PGSC-Calculator files, plus multi-ancestry Million Veterans Program phenome-wide association results.

medRxiv · Jun 11, 2026 · PreprintGenetic & Genomic Medicine✦ In-depth digest

The Polygenic Score Catalog: new functionality and tools to enable FAIR research

Samuel A. Lambert, Benjamin Wingfield, Joel T. Gibson, Laurent Gil, Santhi Ramachandran, Florent Yvon, Shirin C C Saverimuttu, Emily Tinsley, Elizabeth Lewis, Scott C. Ritchie, Jing Qin Wu, Rodrigo Cánovas, Aoife McMahon, Laura Wiseman Harris, Helen Parkinson, Michael Inouye

The paper introduces new features and tools for the PGS Catalog to enhance FAIR research, enabling reproducible and equitable polygenic score calculations.

medRxiv · May 29, 2024 · PreprintGenetic & Genomic Medicine

The Polygenic Score Catalog: an open database for reproducibility and systematic evaluation

Samuel A. Lambert, Laurent Gil, Simon Jupp, Scott C. Ritchie, Yu Xu, Annalisa Buniello, Aoife McMahon, Gad Abraham, Michael Chapman, Helen Parkinson, John Danesh, Jacqueline A. L. MacArthur, Michael Inouye

PGS Catalog standardizes 192 curated polygenic scores and metadata (86 traits); reapplied in UK Biobank, eight of nine colorectal cancer scores predicted disease in European-ancestry participants.

Nature Genetics · Mar 10, 2021Peer-reviewedGenetic & Genomic Medicine✦ In-depth digest